SIGLEC-1 INITIATES FORMATION OF THE VIRUS-CONTAINING COMPARTMENT AND ENHANCES MACROPHAGE-TO-T CELL TRANSMISSION OF HIV-1.

Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.

HIV-1 particles assemble and bud from the plasma membrane of infected T lymphocytes.Infected macrophages, in contrast, accumulate particles within an apparent intracellular compartment known as the virus-containing compartment or VCC.Many aspects of the formation and function of the VCC remain unclear.Here we demonstrate that VCC formation does not

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454 Transcriptome sequencing suggests a role for two-component signalling in cellularization and differentiation of barley endosperm transfer cells.

BackgroundCell specification and differentiation in the endosperm of cereals starts at the maternal-filial boundary and generates the endosperm transfer cells (ETCs).Besides the importance in assimilate transfer, ETCs are proposed to play an essential role in the regulation of endosperm differentiation by affecting development of proximate endosper

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Is the Central Nervous System Reservoir a Hurdle for an HIV Cure?

There is currently no cure for HIV infection although adherence to effective antiretroviral therapy (ART) suppresses replication of the virus in blood, increases CD4+ T-cell counts, reverses immunodeficiency, and increases life expectancy.Despite these substantial advances, ART is a lifelong treatment for people with HIV (PWH) and Pharmaceutical Ac

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