Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.
HIV-1 particles assemble and bud from the plasma membrane of infected T lymphocytes.Infected macrophages, in contrast, accumulate particles within an apparent intracellular compartment known as the virus-containing compartment or VCC.Many aspects of the formation and function of the VCC remain unclear.Here we demonstrate that VCC formation does not